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Pharmakon Plants Peganum harmala

Peganum harmala

Harmal · Espand · Syrian rue

Tradition, ritual & cultural use

Oldest evidenced or proposed human use

Seeds and the name harmal occur in ancient and medieval medical traditions, but archaeological identifications and claims of entheogenic antiquity require caution.

Peoples & traditions

Persian, Kurdish, Afghan, Turkish, North African, Central Asian and other communities use regional forms of harmal/espand practice.

Role in shamanism

Most documented traditional use concerns fumigation against the evil eye, blessing, protection and household ritual rather than a universal visionary sacrament.

Role in physical healing

Used historically for diverse complaints in Unani, Persian and folk medicine. Harmala alkaloids inhibit monoamine oxidase and can be toxic; traditional use does not establish safety.

Cosmology & key terms

> Its smoke turns back the evil eye. — Amin (1991), Iranian medicinal and ritual tradition

Visionary phenomenology

> Dreamlike visual effects occur at toxicologically significant exposure. — Mahmoudian et al. (2002), clinical toxicology

Contemporary status

Common and sometimes invasive outside its native range. Research concerns β-carbolines, antimicrobial and anticancer activity, while online ayahuasca-analogue culture has recast a protective fumigant as an MAOI ingredient; poisoning cases remain clinically significant.

Bibliography

Harvard style (Cite Them Right) · DOI and stable-record links · 3 sources

Chemistry & pharmacology

01 · 2 sources
Mahmoudian, M., Jalilpour, H. and Salehian, P. (2002) ‘Toxicity of Peganum harmala: review and a case report’, Iranian Journal of Pharmacology and Therapeutics, 1, pp. 1–4.
Stable record
Moloudizargari, M., Mikaili, P., Aghajanshakeri, S., Asghari, M.H. and Shayegh, J. (2013) ‘Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids’, Pharmacognosy Reviews, 7(14), pp. 199–212. Available at: https://doi.org/10.4103/0973-7847.120524.

Ethnography, ritual & cosmology

02 · 1 sources
Amin, G. (1991) Popular Medicinal Plants of Iran. Tehran: Iranian Research Institute of Medicinal Plants.
Stable record

Cross-correlations

Cultural complexBrazilian Ayahuasca–Jurema Syncretic Religions Complex — indexed → · Ayahuasca Analogues — indexed →
Shared compoundMaoi Banisteriopsis caapi